Our pharmacist answers the recent question about whether or no your can take Benadryl (diphenhydramine) v Nyquil.

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At a glance

NyQuil has doxylamine, a sedating first-generation antihistamine. Benadryl includes diphenhydramine, additionally a sedating first-generation antihistamine. Use of both together increases the hazard of side effects such together oversedation, dry mouth, dried eyes and constipation.



In most cases, the is not encourage to take it Benadryl (diphenhydramine) and Nyquil together since they both save on computer sedating antihistamines.<1>

The sedating antihistamine in NyQuil is doxylamine, i m sorry is very closely related to diphenhydramine (the active ingredient in Benadryl). In fact, they room in the same course of medication, sedating first-generation antihistamines.

Taking 2 first-generation antihistamines together is thought about "duplicate therapy" and also increases the hazard of side impacts occurring.

What Is Benadryl?

Benadryl is classified together a an initial generation antihistamine. The expression of action of the drug is commonly 4-6 hrs per sheep (25 mg to 50 mg).<2>

First generation antihistamines are known for your sedative effects and also CNS (central nervous system) depressant effects. Plenty of individuals can not tolerate the sedative impacts of Benadryl (diphenhydramine) during the job and, therefore, just take it in ~ bedtime come combat insomnia.

What Is NyQuil?

Nyquil is a combination cold/cough product that has the medicine doxylamine, together with a pain/fever reducer (acetaminophen) and a cough suppressant (dextromethorphan).

Doxylamine is a sedating first-generation antihistamine and is in the same class of medication as Benadryl (diphenhydramine).<3>

Interaction Explained

As declared above, both doxylamine and also Benadryl (diphenhydramine) occupational the same way and room actually in the same course of medication.

They work by prevent the histamine-1 receptor in the body, which prevents histamine indigenous binding come it and producing the symptom we room all very familiar through (e.g. Runny nose, watery eyes, etc...).

Since both drugs work-related the exact same way, utilizing both at the exact same time is not recommended.

Combined use normally won"t administer any much more benefit than taking either alone. Additionally, taking them together not only increases the risk of excessive sedation, it substantially increases the threat of added adverse effects such as:<4>

Dry mouthDry eyesConstipationConstricted airways

Very high sheep of sedating antihistamines have likewise been associated with excitation, agitation, and restlessness.<5>

When Is Use together Okay?

Having stated that, there might be a instance to take the combination together.

Benadryl (diphenhydramine) has relatively strong proof for usage in stemming allergy reactions.

Studies display that Benadryl (diphenhydramine) can effectively reduce itching and swelling from reaction to things like bee stings and poison ivy.

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If you have currently taken a dose of Nyquil and also are having actually an allergy reaction to something, acquisition a sheep of Benadryl (diphenhydramine) may aid without a huge increased threat in intolerable next effects.